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Request for Proposals For Sub-award registration of TB drugs (Second Line Drugs) in Kyrgyzstan

Request for Proposals For Sub-award registration of TB drugs (Second Line Drugs) in Kyrgyzstan USAID Cooperative Agreement No. AID-OAA-A-14-00029

Submit Questions to: bakyt.myrzaliev@kncvtbc.org

Submit Requests for proposals to: gulzat.sultanidinova@kncvtbc.org

Closing Date for Submission of requests for proposals: 9th February 2018

Funded by:United States Agency for International Development (USAID)

Managed by: KNCV Tuberculosis Foundation

 

KNCV Tuberculosis Foundation

KNCV Tuberculosis Foundation (KNCV) is an international non-profit organization dedicated to the fight against tuberculosis (TB) which is still the second deadliest infectious disease in the world. KNCV is an international center of expertise for TB control that promotes effective, efficient, innovative and sustainable TB control strategies in a national and international context. We are an organization of passionate TB professionals, including doctors, researchers, training experts, nurses and epidemiologists. We aim to stop the spread of the worldwide epidemic of TB and to prevent the further spread of drug-resistant TB (DR-TB).

Over the past century we have built up a wealth of knowledge and expertise, initially by successfully controlling TB in the Netherlands. Since the 1970s, we have also shared our knowledge and expertise with the rest of the world. We operate from a central office in The Hague in the Netherlands, a regional office in Central Asia and country offices worldwide. KNCV raises funds from private, institutional, corporate, and government donors.

Challenge TB

KNCV is the lead partner in Challenge TB (CTB) project, the current United States Agency for International Development (USAID)-funded five-year global project to decrease TB mortality and morbidity in high TB burdened countries. We lead an international consortium with eight partner organizations: American Thoracic Society (ATS), FHI 360, Interactive Research & Development (IRD), Japan Anti-Tuberculosis Foundation (JATA), Management Sciences for Health (MSH), PATH, The International Union Against Tuberculosis and Lung Disease (The Union), and the World Health Organization (WHO).

The overarching strategic objectives of CTB are to improve access to quality patients centered care for TB, TB/HIV, and MDR-TB services; to prevent transmission and disease progression; and to strengthen TB platforms. CTB project includes TB control activities in 23 countries and several overarching core projects in multiple countries. For more information, see www.challengetb.org.

Challenge TB in Kyrgyzstan

Kyrgyzstan is one of the countries with the highest prevalence of MDR-TB, with growing numbers of extensively drug-resistant TB (XDR-TB) patients. There was previously no effective treatment available for MDR-TB in the country but current efforts by KNCV and partners are starting to change this.

In Kyrgyzstan, Challenge TB focuses mainly on the provision of technical support by the KNCV/CTB country team, KNCV consultants from the Regional and Central Offices and external experts for the safe introduction of the new TB drugs and shorter regimen for treatment of DR-TB. Since January 2017, the NTP has started to enroll patients on new regimens using Bedaquiline, Delamanid and repurposed TB drugs supplied through the Global Fund from World Health Organization (WHO) pre-qualified manufacturers. Starting from 2019,Kyrgyzstan will gradually finance procurement of TB second line drugs (SLDs). According to the Kyrgyz Regulation № 137, all medicines including TB drugs should be registered in the authorized regulative body. The Kyrgyz market isn’t big and interesting enough for the drugs’ manufacturers to actively register their TB SLDs by themselves. This fact along with the lack of HR capacity and financial resources in the NTP and MOH creates a risk of procurement of TB SLDs from the doubtful manufacturers.

Taken into consideration that procurement of the ineffective, low-quality and counterfeit drugs can lead to further development of drugs-resistance, treatment failures, complications and even deaths, the CTB project is planning to support the NTP in the registration of the TB SLDs through a local consulting company with the profound reputation and experience.

Purpose of Request for Proposal

The purpose of Request for Proposal is to provide technical assistance to the NTP to register second line TB drugs in the respective authorized body according to the Kyrgyz Republic legislative procedure, by hiring a local consulting company.

Scope of Work:

  • Submit the registration dossier and other necessary documentation in accordance with the requirements of the legislation of the Kyrgyz Republic, including the internal normative acts of the authorized agency of the Kyrgyz Republic
  • Provide samples of medicines required for examination, in the quantity required for the threefold analytical study
  • Provide on request of the authorized agency of the Kyrgyz Republic additional information
  • Timely submit materials to the authorized body to conduct registration work
  • Pursue negotiations with producers and with relevant stakeholders
  • Provide, confirming documentation on the registration procedure upon completion, (registration certificate, approved instructions, approved packaging leaflets), issued by the authorized bodies
  • Submit to Country Director or respective technical officer the plan for registration and re-registration of second-line TB drugs
  • Carry out the regulatory work on time
  • Submit payment receipts for the registration service and report on the date of payments in a timely manner
  • Inform the Country Director or respective technical officer on any unforeseen registration issue in a timely manner
  • Translate the whole package of documentation for the registration from English to country official languages (Kyrgyz and Russian).

Timeframe

The work is expected to commence on the 1st of March 2018 and be completed by the 30th of September 2018.

Application process

The proposal must be prepared in accordance with the instructions provided in the below section. Each organization shall submit only one proposal.

Issuance of this RFP does not in any way constitute an award or commitment on the part of the CTB nor does it commit to pay for costs incurred in the preparation and submission of proposal.

To ensure you receive modifications to the RFP, send an email to gulzat.sultanidinova@kncvtbc.org requesting that your organization be put on the distribution list.

 General guidelines for developing requests for proposals

Applicants shall consider the following guidelines for developing the proposal:

  • The proposal should address all activities under section ‘Scope of Work’.
  • Proposed activities described in the proposal should be for the proposed geographic area, i.e. nationwide
  • Applicants can receive funding for similar activities from other donors. However, proposed activities must not be a duplication of activities that are covered or planned under the other funding source, and the organization must make clear how the different funding sources will be used for distinct objectives or distinct geographic areas.

Eligibility criteria

The organization submitting the proposal should meet the following eligibility criteria:

  • Is a reputable local organization legally registered in Kyrgyzstan
  • Has demonstrated presence and activities of similar nature in Kyrgyzstan
  • Has a solid experience in Kyrgyzstan for drug registration
  • Has a capacity to use excellent English and Russian
  • Has demonstrated capacity to manage sub-award and/or contract funds
  • Possesses financial/audit statements of last three fiscal years.

Budget and funding period

A budget should be added in the attached format. The budget should specify all staff levels and numbers needed full-time/part-time (FTE) %, equipment, maintenance, consumables, communication, transport, database set-up and maintenance. The following categories of cost should be used: salary and wages, fringe benefits, travel and transportation, equipment, supplies, contractual, other direct costs, indirect costs.[1] All items should be specified and justified.

Subject to the availability of funds and technical evaluation outcomes, KNCV intends to award one or more sub-awards to local partners under the CTB project.

Funding will depend on USAID funding for this project and therefore funding commitments can only be given for two month periods, with the intention to fund the complete period.

Questions and answers

Questions can be submitted to the following email address until a week before the application deadline: bakyt.myrzaliev@kncvtbc.org . Responses will be provided within three working days to all organizations that have shown interest to apply.

Request for proposals format

The proposal should be prepared in English. Applicants are requested to use A4 size paper, with single space, 10-point font Verdana. The proposal should not exceed six pages excluding the cover page.

The organization will develop a proposal which describes:

  1. Applicant information (name of applicant’s institute/organization, name and title of contact person, mailing address, telephone (including mobile number), email address)
  2. Number and names of staff to -be -involved in this project, including their CVs
  3. Experience in working with the local medical office
  4. Specific proposal on how the activity will be manage

Evaluation criteria

KNCV will establish a Technical Evaluation Panel (TEP) to review and evaluate all proposal papers received before the deadline. Only proposals that meet the eligibility criteria will be considered. The TEP will evaluate the proposal using the following criteria and scoring as described below. The TEP will assign maximum 100 points. Behind each item is the maximum number of points that can be obtained:

  1. TB/Health work experience, as specified above (35 points)
  2. Suitability of specific proposal, as specified above (35 points)
  3. Budget (30 points).

The organization that has been selected to collaborate for developing a full proposal and budget based on their proposal will be notified within one month after the closing date for submission.