GeneXpert MTB/RIF test

The GeneXpert MTB/RIF test from Cepheid HBDC, endorsed by the World Health Organization (WHO) for roll-out in 2010, has tremendous potential for improving TB diagnostic capacity and, as such, TB control in high-burden countries.

The use of the GeneXpert MTB/RIF test is increasing exponentially at a global level. However, resource-constrained countries are faced with some operational difficulties and sub-optimal performance issues. These include, amongst other challenges, the following domains: (i) strategic planning of where to place the GeneXpert MTB/RIF machines; (ii) how to use them in a standardized fashion with a clear diagnostic algorithm; (iii) procurement and supply chain management of GeneXpert MTB/RIF supplies; (iv) required laboratory infrastructure (e.g., UPS, power surge protectors, electricity, air-conditioning, security); (v) training; (vi) routine supervision of laboratory and clinical staff; (vii) monitoring and evaluation of the quality of services (including linkages of the GeneXpert MTB/RIF test result with treatment and treatment outcome);(viii) installation and maintenance; (ix) troubleshooting.

KNCV was appointed as authorized service provider (ASP) for GeneXpert in the year 2014. The major role of KNCV as the ASP is to mitigate the above-mentioned challenges. The Cepheid project covers all GeneXpert in all states in Nigeria (36 + FCT). To achieve part of this broad strategy, KNCV proposes a collaboration with CEPHEID HBDC with a basic service package to support TB control in high-burden and developing countries through National TB control programs, National HIV/AIDS programs and other stakeholders by further ensuring well-functioning GeneXpert MTB/RIF equipment. In 2019, we continued to monitor the project’s Key Performance Indicators to show a reduced repair time for faulty equipment. We organized a stakeholders meeting between Cepheid and the National TB Program to provide lasting solutions including issues of comprehensive & constant warranty coverage and we provided trainings for additional test menus.

Country: Nigeria

KNCV has been fighting TB since its establishment in 1903. Over the past 120 years, the organization has acquired indispensable knowledge and experience in the field of effective TB prevention and care, resulting in pre-elimination in the Netherlands and significant contributions to global evidence generation, policy development and TB program implementation worldwide.

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